Research

Tom and Maryam’s Farewell Dinner (5/13/2017)

Thanks Tom and Maryam for your hard work in the Hibino lab! You are officially alumni now (and this will be reflected in our People page).

Thanks Dr Hibino for the generous treat!

New Publication: Tissue Engineered Vascular Grafts: Current State of the Field.

Expert Rev Med Devices. 2017 Apr 27. doi: 10.1080/17434440.2017.1324293. [Epub ahead of print]

Tissue Engineered Vascular Grafts: Current State of the Field.

Ong CS1, Zhou X1, Huang CY2, Fukunishi T1, Zhang H1, Hibino N1.

Author information

1. Division of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Maryland, USA.
2. Department of Physics & Astronomy, Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

INTRODUCTION:

Conventional synthetic vascular grafts are limited by the inability to remodel, as well as issues of patency at smaller diameters. Tissue-engineered vascular grafts (TEVGs), constructed from biologically active cells and biodegradable scaffolds have the potential to overcome these limitations, and provide growth capacity and self-repair.

Areas covered: This article outlines the TEVG design, biodegradable scaffolds, TEVG fabrication methods, cell seeding, drug delivery, strategies to reduce wait times, clinical trials, as well as a 5-year view with expert commentary.

Expert Commentary: TEVG technology has progressed significantly with advances in scaffold material and design, graft design, cell seeding and drug delivery. Strategies have been put in place to reduce wait times and improve “off-the-shelf” capability of TEVGs. More recently, clinical trials have been conducted to investigate the clinical applications of TEVGs.

KEYWORDS:

Biomaterial; Cell seeding; Tissue Engineered Vascular Grafts; Vascular Grafts; Vascular Surgery

DOI: 10.1080/17434440.2017.1324293

Figure 1 20170316

Accepted Publication: Creation of Cardiac Tissue Exhibiting Mechanical Integration of Spheroids Using 3D Bioprinting

New publication coming soon: https://www.jove.com/video/55438/creation-cardiac-tissue-exhibiting-mechanical-integration-spheroids

JoVE Capture.JPG

Accepted Publication: Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts

Title: Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts

Authors: Takuma Fukunishi, MD1 # , Cameron A. Best, BA2 # , Chin Siang Ong, MD1 , Tyler Groehl, PhD3 , James Reinhardt, PhD2 , Tai Yi, MD2 , Hideki Miyachi, MD, PhD2 , Huaitao Zhang, BS1 , Toshiharu Shinoka, MD, PhD2 , Christopher K. Breuer, MD2 , Jed Johnson, PhD3 , Narutoshi Hibino, MD, PhD1, *

Affiliations:

1 Department of Cardiac Surgery, John Hopkins University, Baltimore, MD
2 Tissue Engineering and Surgical Research, Nationwide Children’s Hospital, Columbus, OH
3 Nanofiber Solutions, Inc. Columbus, OH

# Equally contributing first authors

Journal: Tissue Engineering Part A